Dammarane Sapogenin PPD (Protopanaxadiol) Induces Suicidal of Human Melanoma

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Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview

0 0 The first issue of Natural Product Reports in 2015 will publish a comprehensive review regarding ginseng’s anti-cancer effects and underlying mechanisms. Here we summarize this review as follows:...

Protopanaxadiol

Pharmacological Review of Ginsenoside Dammarane Saponin Rh2

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Pharmacological Review of Ginsenoside Dammarane Saponin Rg1

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Pharmacological Review of Ginsenoside Dammarane Saponin Rb1

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Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxatriol (PPT)

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Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxadiol (PPD)

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Antiallergic activity of ginsenoside Rh2

0 0 The antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliaceae), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a...

107

Rb1 prevents osteoporosis by inhibiting osteoclastogenesis

0 0 Ginsenosides, the main active components of ginseng, have been reported possessing anti-osteoporosis activity in ovariectomized rats. However, the active ingredient and the mechanisms underlying the anti-osteoporosis activity of...

028

PPD induces apoptosis of glioma cells

0 0 20S-Protopanaxadiol (PPD) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponins. In the present study, PPD was used to induce cytotoxicity for two human glioma cell lines,...

132

Rh2 improves insulin sensitivity

0 0 Ginsenoside Rh2, one of the ginsenosides contained in the Panax ginseng root, was employed to screen the effect on insulin resistance of rats induced by a diet containing...

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Related Articles:

The Ginsenoside 20-O-β-D-Glucopyranosyl-20(S)-Protopanaxadiol Induces Autophagy and Apoptosis in Human Melanoma via AMPK/JNK Phosphorylation.
PLoS One. 2014;9(8):e104305
Authors: Kang S, Kim JE, Song NR, Jung SK, Lee MH, Park JS, Yeom MH, Bode AM, Dong Z, Lee KW

Abstract
Studies have shown that a major metabolite of the red ginseng ginsenoside Rb1, called 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (GPD), exhibits anticancer properties. However, the chemotherapeutic effects and molecular mechanisms behind GPD action in human melanoma have not been previously investigated.

Here we report the anticancer activity of GPD and its mechanism of action in melanoma cells. GPD, but not its parent compound Rb1, inhibited melanoma cell proliferation in a dose-dependent manner.

Further investigation revealed that GPD treatment achieved this inhibition through the induction of autophagy and apoptosis, while Rb1 failed to show significant effect at the same concentrations.

The inhibitory effect of GPD appears to be mediated through the induction of AMPK and the subsequent attenuation of mTOR phosphorylation. In addition, GPD activated c-Jun by inducing JNK phosphorylation.

Our findings suggest that GPD suppresses melanoma growth by inducing autophagic cell death and apoptosis via AMPK/JNK pathway activation.

GPD therefore has the potential to be developed as a chemotherapeutic agent for the treatment of human melanoma.

PMID: 25137374 [PubMed – as supplied by publisher]

Source: PPT and PPD

    

Dammarane Sapogenin PPD (Protopanaxadiol) Induces Suicidal of Human Melanoma
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