Classification of ginsenosides

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082

Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview

0 0 The first issue of Natural Product Reports in 2015 will publish a comprehensive review regarding ginseng’s anti-cancer effects and underlying mechanisms. Here we summarize this review as follows:...

Protopanaxadiol

Pharmacological Review of Ginsenoside Dammarane Saponin Rh2

3 0 Please download here. Related PostsAntiallergic activity of ginsenoside Rh2 Rb1 prevents osteoporosis by inhibiting osteoclastogenesis PPD induces apoptosis of glioma cells Rh2 improves insulin sensitivity Antiestrogenic effect of...

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Pharmacological Review of Ginsenoside Dammarane Saponin Rg1

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Pharmacological Review of Ginsenoside Dammarane Saponin Rb1

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Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxatriol (PPT)

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Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxadiol (PPD)

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Antiallergic activity of ginsenoside Rh2

0 0 The antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliaceae), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a...

107

Rb1 prevents osteoporosis by inhibiting osteoclastogenesis

0 0 Ginsenosides, the main active components of ginseng, have been reported possessing anti-osteoporosis activity in ovariectomized rats. However, the active ingredient and the mechanisms underlying the anti-osteoporosis activity of...

028

PPD induces apoptosis of glioma cells

0 0 20S-Protopanaxadiol (PPD) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponins. In the present study, PPD was used to induce cytotoxicity for two human glioma cell lines,...

132

Rh2 improves insulin sensitivity

0 0 Ginsenoside Rh2, one of the ginsenosides contained in the Panax ginseng root, was employed to screen the effect on insulin resistance of rats induced by a diet containing...

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Ginsenosides are main active ingredients in Asian ginseng and American ginseng.

To date, more than 40 ginsenosides are found. Ginsenosides are denoted by -RX (note: X=0、a1、a2、a3、b1、b2、b3、c、d、e、f、g1、g2、g3、h1、h2、h3、s1、s2). In addition, F11 belongs to pseudoginsenoside saponin.

According to their mother ring structure, ginsenosides can be classified into 3 types:

  • oleanolic acid type
  • dammarane type
  • Ocotillol type

Dammarane type saponins account for 70% of total saponins in ginseng, and it can be further categorized into protopanaxadiol-type and protopanaxatriol-type, their mother ring structures are listed below.

Protopanaxadiol       Protopanaxatriol

PPD                                                                              PPT

Chemical processing or hydrolysis in GI tract will convert above two types of ginsenosides into aglycone protopanaxadiol (PPD) and protopanaxatriol (PPT).

Classification of ginsenosides
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