The immunoenhancing property and anti-cancer activity of dammarane sapogenin protopanaxadiol

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Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview

11 0 The first issue of Natural Product Reports in 2015 will publish a comprehensive review regarding ginseng’s anti-cancer effects and underlying mechanisms. Here we summarize this review as follows:...

Protopanaxadiol

Pharmacological Review of Ginsenoside Dammarane Saponin Rh2

3 0 Please download here. Related PostsAntiallergic activity of ginsenoside Rh2 Rb1 prevents osteoporosis by inhibiting osteoclastogenesis PPD induces apoptosis of glioma cells Rh2 improves insulin sensitivity Antiestrogenic effect of...

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Pharmacological Review of Ginsenoside Dammarane Saponin Rg1

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Pharmacological Review of Ginsenoside Dammarane Saponin Rb1

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Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxatriol (PPT)

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Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxadiol (PPD)

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Antiallergic activity of ginsenoside Rh2

0 0 The antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliaceae), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a...

107

Rb1 prevents osteoporosis by inhibiting osteoclastogenesis

0 0 Ginsenosides, the main active components of ginseng, have been reported possessing anti-osteoporosis activity in ovariectomized rats. However, the active ingredient and the mechanisms underlying the anti-osteoporosis activity of...

028

PPD induces apoptosis of glioma cells

0 0 20S-Protopanaxadiol (PPD) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponins. In the present study, PPD was used to induce cytotoxicity for two human glioma cell lines,...

132

Rh2 improves insulin sensitivity

0 0 Ginsenoside Rh2, one of the ginsenosides contained in the Panax ginseng root, was employed to screen the effect on insulin resistance of rats induced by a diet containing...

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The immune system protects the body against infection caused by bacteria, viruses, fungi or parasites. Normal immne cells are able to monitor mutated cells and remove them before they accumulate and grow into solid tumors. The immune system is important to cancer patients in many ways because

  • The cancer can weaken the immune system
  • Cancer treatment can weaken the immune system
  • The immune system may help to fight your cancer

Cancer cells can secret a number of chemicals which act on immune cells so as to evade immunosurveillance. Also, hematological cancers as well as many cancers which spread into the bone marrow can replace normal cells, leading to compromised immune response. Meanwhile, chemotherapy and radiotherapy can weaken immunity by causing a drop in the number of white blood cells made in the bone marrow.

Some cells of the immune system can recognise cancer cells as abnormal and kill them. therefore, they can be utilized as part of immunotherapy to fight cancers.

A research published on China Pharmacist [2007, 10(12)] reported that protopanaxadiol (PPD) can enhance immune response in addition to it direct inhibitory effect to fight tumor.

Scientists created 3 models of liver cancer, Lewis lung cancer and melanoma on mice, and then gave PPD at 25, 50 and 100 mg/kg for 12 days before measuring lymphocyte responsiveness as well as tumor weight and size. In all three cancer models, PPD at all doses increased the transformation rate of lymphocytes, cytotoxic activity of NK cels as well as interleukin-2 level in a dose-dependent manner, and all 3 parameters were decreased in cyclophosphamide treated mice. In addition to the enhancement of immune response, PPD also dose-dependently inhibited tumor growth, with a maximal inhibition of 43%-50% at 100mg/kg. Though the tumor inhibition by PPD was not comparable with cyclophosphamide, PPD-treated mice maintained a body weight similar to the normal control.

Overall, PPD treatment not only shrank tumor size but also enhanced immune response, and no toxicity was observed in the study. The results are in solid  support of PPD’s use in cancer treatment.

The immunoenhancing property and anti-cancer activity of dammarane sapogenin protopanaxadiol
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